Urinary evaluation of the balance between soluble interferon-gamma receptor (IFN-γR1) and interleukin-4 receptor (IL-4Rα)

    loading  Checking for direct PDF access through Ovid

Abstract

To elucidate the usefulness of the simultaneous analysis of multiple kinds of soluble cytokine receptors in urine specimens, we determined the levels of both the soluble interferon-gamma receptor α chain (sIFN-γR1, Th1-type cytokine receptor) and the soluble interleukin 4-receptor α chain (sIL-4Rα, Th2-type cytokine receptor) in the urine of healthy subjects as reference values and preliminarily applied this method to evaluate patients with diarrhea positive (D+) hemolytic uremic syndrome (HUS) as the diagnostic parameters. The urinary sIFN-γR levels of children were significantly lower than those of adults (p < 0.01, n = 107). On the other hand, there was no significant difference between the urine sIL-4R levels of adults and children. Statistical correlation between sIFN-γR and sIL-4R values was not observed (p = 0.705). On the day of onset of HUS, the urine sIFN-γR levels of the patients (n = 6) with HUS were higher than those of the healthy control group (n = 67) (p < 0.01); however, there was no significant difference in the sIL-4R levels between both groups. The urine evaluation of the balance between the soluble cytokine receptors might be informative for the immune states of HUS patients.

Related Topics

    loading  Loading Related Articles