IL-38 alleviates concanavalin A-induced liver injury in mice

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Interleukin (IL)-38 is a poorly characterized cytokine of the IL-1 family with anti-inflammatory activity. The role of IL-38 in liver injury remains unknown. We have investigated the potential effect of hydrodynamic-based gene delivery to express human IL-38 in mice with concanavalin A (Con A)-induced liver injury. Transfer of plasmid DNA encoding IL-38 significantly reduced hepatic toxicity and serum levels of aspartate aminotransferase and alanine aminotransferase compared with administration of a control plasmid. Moreover, IL-38 expression dramatically reduced serum levels of several pro-inflammatory cytokines, such as tumor necrosis factor-α, interferon-γ, IL-6, IL-17, and IL-22, but not levels of the anti-inflammatory cytokine IL-10. These results suggest that in vivo expression of human IL-38 in mice has hepatoprotective effects against Con A-induced liver injury by inhibition of inflammatory cytokine production.HighlightsIL-38 inhibits Con A-induced liver injury in mice.IL-38 reduces hepatic toxicity and serum levels of AST and ALT.IL-38 decreases levels of TNF-α, IFN-γ, IL-6, IL-17, and IL-22 in Con A-treated mice.IL-38 may offer a novel therapeutic approach to treat inflammatory liver diseases.

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