Experimental Cerebral Emboli: Angiographic Evaluation of Autologous Emboli in the Dog

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An experimental model is described for introducing autologous emboli into the cerebrovascular tree of the dog. Findings are limited primarily to the arteriographic appearance of the emboli over a 24-hour period. Emboli usually lodge initially in the main trunk of the middle cerebral artery or in one of its larger branches. Following initial blocking of the vessel, there is a rapid distal migration of embolic material which probably is due to lysis in combination with fragmentation. Half the animals died within 24 hours of embolization and all had acute infarction on postmortem examination. Arteriograms of the surviving animals made 24 hours post-embolization showed significantly smaller emboli or emboli which were no longer visible. However, these animals all had areas of cerebral infarction when sacrificed later.

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