Further Toxicity Studies with Methylglucamine Contrast Agents

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By measuring the cardiovascular effects on dogs of carotid artery injections of contrast media, the toxicity of methylglucamine metrizoate was compared to that of a mixture of calcium and methylglucamine metrizoate. Methlglucamine iothalamate was compared to a dimer of methylglucamine iothalamate. Addition of calcium salts or dimerization did not lower the toxicity of the methylglucamine salts.

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