Adhesive Contrast Material in the Canine Upper Urinary Tract

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Effects of adhesive contrast material (ACM) on the kidney were studied in renal arteriography, isolated kidney perfusion, and retrograde pyelography. Lactic dehydrogenase, glutamic-oxalacetic transaminase, creatine phosphokinase, and catalase levels in renal vein blood and urine were measured as an index of renal damage. In low doses (0.08 ml/kg weight), ACM produced prolonged (5 sec) opacification of the arterial bed by coating the vessel walls, and caused less enzymuria than the comparable radiographically useful dose of currently used media. In a perfused kidney, ACM did not produce the usual vasodilatation response, and the peak of the vasoconstrictive phase was higher than that for sodium diatrizoate, presumably due to the high viscosity of ACM. Retrograde pyelography with ACM produced prolonged visualization and coating of the renal pelvis and pyramids, and caused no histologic changes. ACM is thus a potentially useful agent in the study of the upper urinary tract.

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