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The in vitro effects of iopanoic acid (Telepaque), adipiodonmeglumine (Biligrafin), and meglumine amidotrizoate (Angiografin) on the cholinesterase activities of human red blood cells and plasma were studied using radiochemical and titrimetric methods. Significant inhibition of both erythrocyte and plasma cholinesterase activities was caused by biliary contrast media in concentrations which apparently are achieved locally in clinical practice. The initial concentration in angiographic studies may also rise high enough to influence cholinesterase activity since one tenth the original concentration of Angiografin was seen to cause cholinesterase inhibition exceeding 50%. The contrast media studied equally inhibited both specific and nonspecific cholinesterase activities.