Relationship of Bile Salts and Bile Flow to Biliary Excretion of Iopanoic Acid

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The relation between sodium taurocholate and the biliary excretion of iopanoic acid was investigated in dogs. Interruption of the enterohepatic circulation produced a bile flow of 0.05 to 0.15 ml/kg/15 min. and a maximum iopanoic acid excretion of 1.29 mg/kg/15 min. Replacement of bile salts by sodium taurocholate infusion increased bile flow to 0.4 ml/kg/15 min., and the excretion rate of iopanoic acid reached 5.8 mg/kg/15 min. At a constant iopanoic infusion rate of 0.69 mg/kg/min., an increase in sodium taurocholate infusion from 0.69 to 2.08 mg/kg/min. did not cause a further increase in the excretion of iopanoic acid. Biliary excretion of iopanoic acid appeared to depend strongly on the availability of bile salts. There appeared to be an optimum effective dose of sodium taurocholate needed to produce maximum biliary excretion of iopanoic acid. Iopanoic acid did not have any choleretic effect.

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