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Endoscopic retrograde cholangiography (ERC) allows visualization of the entire biliary tree. The cholangiographic appearance of the intrahepatic bile ducts has received relatively little attention. This postmortem study was performed to define cholangiographic alterations produced by disease and to aid in the recognition of pathologic intrahepatic cholangiographic patterns produced by ERC. Intrahepatic cholangiographic patterns in the normal biliary tree, hepatic cirrhosis, hepatic infiltrative processes, and hepatic mass lesions are presented.