Effect of Elevated C-Esterase Inhibitor Concentrations on White Blood Cell-Endothelium Interactions A Potential Mechanism for Steroid Protection in Contrast Material Reactions

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Purified human C-esterase inhibitor (CINH) infused into the circulation of rabbits caused an immediate drop in white blood cell (WBC) count and, simultaneously, a marked decrease to WBC adhesion to the endothelium in the microcirculation. Infusion of iodipamide caused a marked “carpeting” of the venous endothelium by WBC,_and this condition was reversed by subsequent infusion of C1INH. The relationship of elevated C1INH to the protective effect of prednisolone on iodipamide toxicity in the rabbit is discussed.

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