Serioangiographic Study of Protective Action of Cyproterone Acetate Against Renal Vasospasm Following Testosterone plus Vasopressin Administration in Rats

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A serioangiographic method has been used to study the renal circulation after vasopressin administration in rats pretreated for ten days with testosterone-phenylpropionate. The treatment was found to induce a spasm localized to the larger renal arteries, which may be of pathogenetic importance in the development of renal cortical necrosis. When the androgen receptor blocker cyproterone acetate was administered simultaneously with the testosterone, vasopressin did not give rise to a subsequent renal vasoconstriction. The results suggest a role of the androgen receptors in the kidney in the induction of the phenomenon.

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