In Vivo Measurement of Proton Diffusion in the Presence of Coherent Motion


    loading  Checking for direct PDF access through Ovid

Abstract

Johnson GA, Maki JH. In vivo measurement of proton diffusion in the presence of coherent motion. Invest Radiol 1991;26:540-545.Measurement of the self-diffusion coefficient D of water in tissue has been performed traditionally using the technique proposed by Stejskal and Tanner. A variant of that technique is shown here, employing flow-compensated gradients that significantly reduce the sensitivity to small coherent motions that are common in body imaging. An interleaved sequence with four values of diffusion-sensitizing gradient (b) minimizes registration errors. Eddy currents and other systematic errors are reduced, permitting the measurement of standards in an imaging context within 5% of nonimaging values in the literature. The flow-compensated sequence permits the measure of D for tissues in the abdominal cavity of the rat. We present in vivo measurements of D for the following rat tissues: liver, kidney (cortex), kidney (medulla) muscle, brain, fat.

    loading  Loading Related Articles