Tackling drug-resistant Gram-positive infection

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The emergence of resistance in many clinically important Gram-positive bacteria is seriously limiting the choice of therapeutic agents, and there are now some enterococci that have shown some degree of resistance to all currently used drugs, according to Dr DF Sahm of the Washington University Medical Center in St Louis, US. Vancomycin resistance is becoming increasingly prevalent among enterococci and the possibility of it transferring to methicillin-resistant staphylococci is a real danger. New agents which are structurally different to agents associated with resistance are needed. These issues were discussed at the 33rd Interscience Conference on Antimicrobial Agents and Chemotherapy held in New Orleans, US, last month.

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