Lacosamide strong on pain in diabetic neuropathies

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Lacosamide [SPM 927] is an effective treatment for pain in patients with distal diabetic neuropathy, according to results of a phase III study presented at the 58th Annual Meeting of the American Academy of Neurology (AAN) [San Diego, California, US; April 2006]. Compared with placebo, lacosamide 400 mg/day was associated with a significant reduction from baseline in pain scores during the last 4 weeks of the 18-week study. Furthermore, lacosamide showed significant benefits over placebo with respect to patients' global impression of change in pain (PGIC). A second open-label follow-on trial in patients with painful diabetic neuropathy who received treatment for up to 32 months showed that the benefits of lacosamide are maintained long-term.

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