Neutrophil antibodies are clinically important

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Neutrophils or polymorphonuclear neutrophils (PMNs) make up the largest proportion (45 – 70%) of circulating leukocytes and play a pivotal role in innate immunity. Thus, patients with low PMN counts (neutropenia) or defective PMN function are more likely to be overwhelmed by infection. PMN reactive antibodies can cause either allo- or auto-immune neutropenias. In some transfusion-related acute lung injury (TRALI) events, donor derived neutrophil reactive antibodies can cause inappropriate activation of neutrophils leading to collateral damage of the surrounding pulmonary microvasculature with potentially grave clinical consequences.

Discussion & Conclusion

Clinical outcomes of TRALI and immune neutropenias demand rapid and precise diagnosis using reliable neutrophil serology. The ISBT Granulocyte Immunobiology Working Party brings together members working in diagnostic laboratories, research and clinical fields to enable strong and productive interactions, innovation and collaboration in granulocyte immunobiology, function and pathology.

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