Vacuum-assisted closure (V.A.C.®) Therapy (KCI International, San Antonio, TX) has been widely used in hospital settings. However, use of V.A.C.® Therapy in home health settings outside of the United States of America (USA) is often limited because of financial considerations. This review paper considers the published evidence on V.A.C. Therapy in home health settings from the USA and beyond and explores the potential economic implications of V.A.C. Therapy in home health settings.