A pilot trial of treprostinil for the treatment and prevention of digital ulcers in patients with systemic sclerosis

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Abstract

We performed a pilot trial of subcutaneous treprostinil for the treatment of digital ulcers in scleroderma. Of the 5 patients completing therapy, ulcer size significantly decreased and no new ulcers occurred on continuous therapy. Although effective, the high rate of injection site reactions may limit the utility of this therapy.

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