Risk of venous thromboembolism in patients with mycosis fungoides and parapsoriasis: A Danish nationwide population-based cohort study

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Abstract

Background:

Mycosis fungoides (MF) and parapsoriasis are characterized by malignant proliferation and chronic inflammation, which may affect the risk for venous thromboembolism (VTE).

Objectives:

To examine the risk for VTE in patients with MF and parapsoriasis.

Methods:

We conducted a nationwide population-based cohort study in Denmark to examine the relative risk (RR) of VTE in 525 patients with MF and 634 patients with parapsoriasis compared with that in sex- and age-matched controls from the general population.

Results:

In patients with MF, the 10-year absolute risk for VTE was 3.4% (95% confidence interval [CI], 2.0–5.4). The adjusted RRs were 2.41 (95% CI, 1.49–3.90) for VTE and 4.01 (95% CI, 2.16–7.46) for pulmonary embolism. Notably, within the first 5 years after diagnosis with MF, the RR of pulmonary embolism was increased 6.7-fold (to 6.71 [95% CI, 2.86–15.72]). Patients with parapsoriasis had a 2.7-fold increased RR of VTE (to 2.67 [95% CI, 1.32–5.40]) in the absence of other established VTE risk factors.

Limitations:

We had no information regarding disease stage of MF and prescribed drugs.

Conclusion:

Patients with MF and parapsoriasis had an increased RR of VTE, although the absolute risk remained low. These findings should increase awareness of comorbidities in patients with MF and parapsoriasis.

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