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The simultaneous presence of multiple conditions in one patient (multi-morbidity) is a key challenge facing primary care.The purpose of this study was to determine the prevalence of multi-morbidity and to document changes in prevalence during the last 25 years.Cross-sectional study using multiple years (1988—2014) of the National Health and Nutrition Examination Survey (NHANES) were analyzed.Multiple years (1988 to 2014) of the National Health and Nutrition Examination Survey (NHANES) from the United States were analyzed.Noninstitutionalized adults.Number of chronic conditions per individual analyzed by age, race, gender, and socioeconomic factors.A total of 57,303 individuals were surveyed regarding the presence of multi-morbidity in separate surveys spanning 1988—2014. The overall current prevalence in 2013—2014 of >2 morbidities was 59.6% (95% CI 58.1%—61.1%), 38.5% had 3 or more, and 22.7% had 4 or more morbidities, which was significantly higher than in 1988 (45.7%, 95% CI 43.5%—47.8%, with >2 morbidities). Among individuals with 2 or more morbidities, 54.1% have obesity compared to 41.9% in 1988. Among adults age >65, prevalence was 91.8% for 2 or more morbidities. Whites and Blacks had significantly higher prevalence (59.2% and 60.1%) than Hispanic or “other” race (45.0%,P< .0001). Women (58.4%) had more current multi-morbidities (>2) than men (55.9%,P= .01).Multimorbidity is common and has been increasing over the last 25 years. This finding has implications for public health policy and anticipated health costs for the coming years.