Misuse and abuse of prescription medications is increasing across both socioeconomic and age parameters. This article includes a review of the uses of Wellbutrin®, and its current misuse/abuse within the correctional setting. It includes a discussion regarding the pharmacodynamics involved in substance abuse. A review of current literature includes both academic research and public forums regarding this topic. It also discusses the role of dopamine in both Wellbutrin® and substance use. The author identifies the lack of current research regarding this topic and poses ethical questions for the provider.