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This study sought to delineate the relations between work addiction and professional quality of life among nurses in university hospitals. The differences between compassion satisfaction, burnout, and secondary traumatic stress by work addiction tendency were investigated among 278 Korean nurses. Results revealed that 46.5% of participating nurses had mild or high work addiction, and nurses with high work addiction tended to have higher burnout and secondary traumatic stress. Factors influencing burnout were work addiction and daily work hours. Only work addiction influenced secondary traumatic stress. Therefore, concern, understanding, and prevention of nurses’ work addiction are needed, as work addiction could affect nurses’ professional quality of life.