Interventions for Nongenital Molluscum Contagiosum in Persons Without Immune Deficiency

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Clinical QuestionHow effective and safe are treatments for nongenital molluscum contagiosum in persons without immune deficiency?Bottom LineCompared with placebo, imiquimod, 5%, cream was not more effective in clearing molluscum contagiosum and caused more local adverse effects, including application site reactions, in children aged 2 to 12 years; because high-quality evidence for other interventions is lacking, allowing for natural resolution of the infection remains a reasonable approach.

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