G-108 Special lecture: HIV-1 prevention

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Abstract

AIDS is a preventable disease. Nevertheless, 2.1 million individuals were infected worldwide in 2015 and therefore an effective vaccine would be highly desirable. Most vaccines in clinical use today prevent infection because they elicit antibodies that block pathogen entry, and studies in experimental animals suggest that pre-existing broadly neutralizing antibodies to HIV-1 can prevent infection. However, despite a significant effort by numerous investigators over the last 30 years eliciting potent antibodies with neutralizing breadth against HIV-1 by vaccination has not been possible. Recent progress toward the goal of active or passive HIV-1 vaccination will be summarized.

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