Human immunodeficiency Virus (HIV), Hepatitis B virus (HBV), and Hepatitis C virus (HCV) are the 3 most common chronic viral infections all over the world. Despite their biological differences, these viruses share similar transmission routes, including sexual, blood contact, and injecting drug use. HCV, HBV, and HIV infections are one of the most important public health problems today. However, there is limited information on their prevalence, distribution and clinical significance in Kenya, where the prevalence of HBV-HCV and HIV co-infections have not been well established. The reason is that there has not been an established gold standard diagnostic system. Poverty, inadequate adequate medical services and facilities, poor quality of education services, cultural or social barriers and political turmoils are but a few of the many factors that do facilitate the long-term spread of these co-infections. The objective of the study is to determine the prevalence of HBV-HCV and HIV co-infections among fishermen patients attending Homabay District Hospital. This is a laboratory based study. Patient samples are to be obtained from fishermen patients attending Homabay district Hospital, which is a referral hospital in Homabay County for nearby clinics in its environs and tested for HIV, HBV and HCV; arc HIVed samples from those stored at the Hospital are also to be analyzed. The genotypes are to be analyzed using a polymerase chain reaction machine. The results will provide information on the Hepatitis B, Hepatitis C and HIV situation in the region, assist the decision makers to develop strategies for improvement, identify and disseminate good practices between clinics the region. The study will also help to interpret results; identify groups at risk of HBV-HCV and HIV infections suggest further research to assist in the improvement of HCVcontrol program at the facility; provide results of the study to the management and staff at the facility. In this study, the collected data is to be analyzed using SPSS Version 22 software.