P-E2 Co-occurrence Network Analysis of Adverse Events for Typhoid Fever Vaccines in VAERS

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Abstract

Salmonella enterica serotype Typhi is considered as one of the high- priority potential bioterrorism agents by the Center for Disease Control and Prevention (CDC). Vaccines against Typhi can help with the prophylaxis against typhoid fever. However, little effort has been conducted for post- market safety monitoring of typhoid fever vaccines. In this paper, we proposed a novel network-based computational approach to investigate the co-occurrence relationships among adverse events reported after typhoid fever vaccine (TYP). We focused on association data that were recorded in the Vaccine Adverse Event Reporting System (VAERS) between 1990 and 2014. First, we extracted and summarized adverse event (AE) information from TYP related reports in the VAERS database using Resource Description Framework (RDF). Then, we applied a series of network approaches to the AE co-occurrence network to identify potential associations among these AEs. Specifically, we (1) constructed an AE co-occurrence network after the typhoid fever vaccines; (2) calculated network properties of AE co-occurrence network; (3) identified condensed subnetworks in AE co-occurrence network; and (4) compared MedDRA terms associated with AEs in each subnetwork. We observed that (1) AE co-occurrence network shares the same scale-free network property as other biological networks and social networks; (2) AEs clustered in one subnetwork are usually enriched in certain MedDRA terms.

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