A-102 Antibody binding to HIV-1 infected cells as mechanism for treatment of HIV infection

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Abstract

Anti-HIV antibody function is not limited to capturing free virus but also includes the recognition of HIV-1 infected cells. Both neutralizing and nonneutralizing antibody responses recognizing HIV-1 envelope epitopes expressed on the cellular membrane can recruit Fc receptor-bearing cells and direct their cytotoxic activity against the infected cells. We can leverage on our ability to use monoclonal antibody and monoclonal antibody-based molecules to protect from and treat HIV-1 infection.

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