Tubal Ligation, Hysterectomy, And Risk of Ovarian Cancer: A Prospective Study

    loading  Checking for direct PDF access through Ovid



To assess whether tubal ligation and hysterectomy affect subsequent risk of ovarian cancer.


Prospective cohort study with 12 years of follow-up.


United States, multistate.


A total of 121 700 female registered nurses who were 30 to 55 years of age in 1976; the follow-up rate was 90% as of 1988.


Ovarian cancer of epithelial origin confirmed by medical record review.


We observed a strong inverse association between tubal ligation and ovarian cancer, which persisted after adjustment for age, oral contraceptive use, parity, and other ovarian cancer risk factors (multivariate relative risk (RR), 0.33; 95% confidence interval (CI), 0.16 to 0.64). The association was similar when we assessed tubal ligation status at the baseline questionnaire and excluded cases in the first 4 years to eliminate any possible short-term decrease in risk due to screening of the ovaries during ligation surgery. We noted a weaker inverse association between simple hysterectomy and ovarian cancer (RR, 0.67; 95% CI, 0.45 to 1.00). Neither vasectomy nor condom use by a partner was associated with risk of ovarian cancer.


These data indicate that tubal ligation, and perhaps hysterectomy, may substantially reduce risk of epithelial ovarian cancer.

Related Topics

    loading  Loading Related Articles