A Reevaluation of Risk of In Utero Exposure to Lithium.

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Abstract

Objective

To reevaluate the risk associated with in utero exposure to lithium.

Conclusion

While initial information regarding the teratogenic risk of lithium treatment was derived from biased retrospective reports, more recent epidemiologic data indicate that the teratogenic risk of first-trimester lithium exposure is lower than previously suggested. The clinical management of women with bipolar disorder who have childbearing potential should be modified with this revised risk estimate.

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