Interventions for Rosacea

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Clinical Question

Which interventions are associated with highest efficacy and fewest adverse events for treating rosacea?

Bottom Line

There is high-quality evidence that topical brimonidine, azelaic acid, and ivermectin, as well as oral doxycycline and isotretinoin, are associated with improvements in rosacea. Lower-quality evidence is available for topical metronidazole, oral tetracycline, laser and light-based therapy, and topical cyclosporine for ocular rosacea. Most treatments are not associated with higher adverse event rates than placebo.

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