Alcohol use among persons living with HIV (PLWH) is consequential. More than half of PLWH have reported having a drink of alcohol and about 8% have reported heavy drinking. Alcohol use in PLWH has been associated with a higher risk of nonadherence to antiretroviral treatment (ART) and poor treatment outcomes. We provide guidance to clinicians for using an evidence-based approach to intervene and ensure follow-up for PLWH who drink alcohol. This set of clinical strategies, known as screening, brief intervention, and referral to treatment, when fully disseminated may help address the 90-90-90 targets proposed by the Joint United Nations Programme on HIV/AIDS, in particular in the receipt of sustained ART and the attainment of viral suppression.