Pharmacokinetics of ganciclovir in haematopoietic stem cell transplantation recipients with or without renal impairment

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Abstract

Objectives

We investigated the pharmacokinetics of ganciclovir in 12 haematopoietic stem cell transplantation (HSCT) recipients to evaluate the validity of a 50% reduction in the ganciclovir dosage for mild renal impairment.

Patients and methods

Ganciclovir at 5 mg/kg/day was pre-emptively infused in patients with estimated CLCR ≥ 70 mL/min (Group A), whereas the dose was reduced to 2.5 mg/kg/day in patients with CLCR between 50 and 70 mL/min (Group B).

Results

The peak concentration was significantly higher in Group A (P < 0.01). However, the decrease in the plasma ganciclovir concentration was slower in Group B (P=0.09), and the AUC of all patients in both groups was distributed within a narrow range (25.6 ± 4.77 μg·h/mL), when two patients with exceptionally high AUC values were excluded.

Conclusions

A 50% reduction in ganciclovir appeared to be appropriate for patients with mild renal impairment. Measuring the ganciclovir concentration at 4 h after starting infusion may be adequate for evaluating AUC.

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