Acute Retinal Necrosis Associated With Epstein-Barr Virus: Immunohistopathologic Confirmation

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Abstract

IMPORTANCE

Acute retinal necrosis (ARN) is an infectious retinitis primarily caused by the herpesviruses. Although the Epstein-Barr virus (EBV) has been implicated as a cause of ARN, to our knowledge, there has been no histopathologic documentation. We report the clinical history and histopathologic confirmation that EBV can cause ARN.

OBSERVATIONS

Clinical course and histopathology of a patient diagnosed with ARN caused by infection with EBV confirmed by molecular pathology.

CONCLUSIONS AND RELEVANCE

Epstein-Barr virus is a recognized cause of intraocular inflammation and has been implicated as a possible cause of ARN. However, to our knowledge, tissue demonstration of EBV in a patient with ARN has not previously been reported. We identified the organism in the necrotic retina of a patient receiving immunosuppression because of idiopathic pulmonary fibrosis.

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