BACKGROUND: Multiple sclerosis (MS) is a disease with significant psychosocial adjustment challenges. OBJECTIVE: The objective of the study was to assess the psychosocial adjustment and coping strategies in patients with MS and to put forth the relationships between them. DESIGN: The sample group comprised 85 outpatients with MS who were admitted to the Neurology Clinic of a university hospital for treatment between October 2007 and July 2008. Data were acquired via an information form and the Psychosocial Adjustment to Illness Scale and Coping Strategy Indicator. RESULTS: It was determined that 55% of the patients had poor psychosocial adjustment levels. Statistically significant relationship was found between Psychosocial Adjustment to Illness Scale–Self-Report and problem solving as well as seeking social support coping strategies (p < .01). Psychosocial adjustment got worse with decreasing problem-solving and seeking–social support coping strategies of patients. CONCLUSIONS: The psychosocial adjustment to MS of patients is closely related with effective coping strategies. The results have emphasized the significant role of mental health and social services and coping strategies regarding the comprehensive care needs of these patients.