A Matched Study to Determine Whether Low-Dose Aspirin Without Heparin Improves Pregnancy Rates Following Frozen Embryo Transfer and/or Affects Endometrial Sonographic Parameters

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The objective of the matched, controlled study was to determine whether low-dose aspirin therapy without heparin improves pregnancy rates following frozen embryo transfer.


Thirty-six women who did not achieve a pregnancy following fresh embryo transfer and who had frozen embryos available for another transfer were included. Eighteen women were treated with 81 mg aspirin from day 2 of the cycle through pregnancy testing. If the β-human chorionic gonadotropin level was positive, aspirin was continued through the pregnancy. Eighteen women were not given aspirin. The mean outcome variables were pregnancy and implantation rates.


The clinical pregnancy rate in the aspirin group was 11.1%, compared with 33.3% for the controls, and implantation rates were 2.9 and 10.9%, respectively.


No positive effects of low-dose aspirin therapy on pregnancy rates following frozen embryo transfer were observed.

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