Pregnancy outcomes in oocyte donation recipients: vaginal gel versus intramuscular injection progesterone replacement

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Compare outcomes with vaginal gel versus intramuscular progesterone replacement in donor oocyte recipients.


A single-center retrospective analysis (January 2004-December 2006) evaluated pregnancy outcomes (serum human chorionic gonadotropin, implantation, clinical pregnancy, delivery, total pregnancy loss rates) for 225 recipients of embryos from donor (aged <32 years) oocytes. Vaginal progesterone gel (Crinone® 8%; 90 mg twice daily; n=105) or intramuscular progesterone (50 mg once daily; n=120) was started the afternoon of oocyte retrieval and continued until a negative pregnancy test or 10 weeks' gestation.


There were no statistically significant differences between groups for the five pregnancy outcomes; numerical results favored vaginal progesterone in all cases. Confidence intervals showed vaginal gel was within, or <1% from, a noninferiority limit of 10% versus intramuscular progesterone for four of five pregnancy outcomes.


Pregnancy outcomes were comparable for progesterone replacement with vaginal gel and intramuscular progesterone in an oocyte donation program.

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