Chronic Indomethacin Administration Blocks Increased Body Temperature After Burn Injury in Rats

    loading  Checking for direct PDF access through Ovid

Abstract

This study investigates the hypothesis that continuous administration of indomediacin (a cyclo-oxygenase inhibitor) will chronically reduce body temperature (TB) in burned rats (ie, modulate “true” fever). Male Sprague-Dawley rats had radio transmitters and osmotic pumps (containing indomethacin) placed in the peritoneal cavity, and 7 days later large full-thickness scald burns were produced. Activity and TB were continually recorded through the 14di postburn day (PBD). There were 4 experimental groups: burn + indomethacin (B-In), n = 9; burn + polyediylene glycol (B-Peg), n = 6; control + indomediacin (C-In), n = 9; and control + polyediylene glycol (C-Peg), n = 6. From PBD 5 through PBD 10, the B-Peg group had consistently and significantly higher TB during light hours than the B-In, C-In, and C-Peg groups. From PBD 7 through PBD 12, the B-In group had an average TB during light hours significantly lower or not different than the C-In and C-Peg groups. These results support the hypothesis that in this burned-rat model chronically increased TB during the light hours may be “fever” (rather than hyperthermia) and that the final effector link could be a prostanoid because changes in activity do not explain the changes in body temperature. (J Burn Care Rehabil 1998;19:501–11)

Related Topics

    loading  Loading Related Articles