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Most metal-on-metal hip resurfacing (MoMHR) designs have experienced high short-term failure rates because of pseudotumors. The impact of this complication into the second decade after the procedure is unknown. We investigated (1) the prevalence of, and risk factors for, all-cause and pseudotumor-related revision at up to 15 years following MoMHR and (2) whether risk factors were sex-specific.This single-center prospective cohort study included 1,429 MoMHRs (1216 patients; 40% female) implanted between 1999 and 2009. Patients were contacted in 2010 and 2012 as per national recommendations. Patients with symptoms related to the hip and/or suboptimal Oxford Hip Scores (≤41 of 48 points) underwent cross-sectional imaging and blood metal-ion sampling. Revision diagnoses were established using operative and histopathological findings. Multivariate Cox proportional hazard models were used to assess the association of predictor variables with the time to all-cause and pseudotumor-related revisions.One hundred and eighty MoMHRs (12.6%) were revised for all causes, and 111 (7.8% of the series and 61.7 % of all revisions) were revised because of pseudotumor. Survival analysis showed the 15-year cumulative revision rate for all causes to be 19.5% (95% confidence interval [CI] = 16.2% to 23.2%) and the 15-year rate of revision due to pseudotumor to be 14.0% (95% CI = 11.0% to 17.7%). Small femoral head size (hazard ratio [HR] per 2 mm = 0.92, 95% CI = 0.88 to 0.97; p = 0.003) and certain implant designs (HR = 1.55 to 3.01; p ≤ 0.029) significantly increased the all-cause revision risk. Female sex (HR = 2.03, 95% CI = 1.19 to 3.44; p = 0.009) and young age (HR per year = 0.98, 95% CI = 0.96 to 1.00; p = 0.020) significantly increased the pseudotumor-related revision risk but not the all-cause revision risk. Risk factors for all-cause and pseudotumor-related revision were sex-specific. In females, small femoral head size (p = 0.014) increased the all-cause revision risk, and young age was the only predictor of pseudotumor-related revision (p = 0.019). In males, implant design was the only predictor of all-cause revision (p ≤ 0.015) and pseudotumor-related revision (p = 0.001).The prevalence and rates of revision for all causes and pseudotumor were high at up to 15 years following MoMHR. Predictors of revision differed between all-cause and pseudotumor-related revisions and were sex-specific. These factors must be appropriately weighted when risk-stratifying patients with MoMHRs for surveillance.Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.