Localized Amyloidosis of the Lower Respiratory Tract

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Abstract

A rare case of localized amyloidosis of the lower respiratory tract in a 54-year-old Japanese man is presented. This patient consulted a physician with chief complaints of cough, sputum, and fever in May 1995. His symptoms were alleviated temporarily by antibiotic administration but recurred frequently. He was then referred to our outpatient department for further evaluation. Chest computed tomography revealed an irregular thickening of the bronchial wall and a narrowing of the bronchial lumen from the trachea to the bilateral main bronchus. Bronchoscopy showed multiple coalesced nodules from the trachea to the bilateral segmental bronchus. The nodular lesions tended to bleed easily and the wall appeared irregular and narrowed. Amyloid protein was detected in a bronchial biopsy. No lesions were detected in other organs. Based on these findings, primary localized amyloidosis of the lower respiratory tract—a rare condition—was diagnosed.

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