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We examined the usefulness of an interventional radiology–computed tomography (IVR-CT)/angio system (Toshiba Medical Corp., Japan) in bronchial arterial infusion (BAI) of anticancer agents. We compared the degrees of tumor response and tumor blush between conventional digital subtraction angiography (DSA) and angio-CT. Nineteen patients with lung cancer and 1 with a mediastinal tumor were included in this study. Angio-CT was performed during arterial infusion. Of the 20 patients, 11 showed a partial response (PR), 3 showed a minor response (MR), and 5 showed no change (NC). Case no. 1 showed an intense tumor blush in both DSA and angio-CT, and achieved PR (partial response). Case no. 2 exhibited moderate tumor blush in DSA but none in angio-CT, and showed NC without any tumor response. In case no. 3, angio-CT revealed that the tumor was supplied by 3 feeding vessels. Angio-CT also provided information on any overflow of contrast medium into the spinal nerve or esophagus, which resulted in greater safety in conducting arterial infusion. We conclude that the combined use of angio-CT with conventional DSA is very effective while performing arterial infusion of anticancer agents, because this modality makes it possible to predict the therapeutic effects, identify an accurate infusion area, and establish the safety of arterial infusion.