This review aims to compile recent advances regarding the significance of Notch signaling in different types of intrahepatic cells during liver injury and repair. The functions of Notch signaling in regulating cell development, fate decisions, and organ homeostasis have been widely acknowledged. Notch is also expressed and activated in hepatocytes, macrophages, liver sinusoidal endothelial cells, endothelial progenitor cells, and hepatic progenitor cells during the process of development, injury, inflammation, fibrosis, and carcinoma. During acute/chronic liver injury, Notch interacts with many signaling pathways that are involved in liver repair. Recent research, including ours, has confirmed the crucial role of Notch signaling in modulating the function of diverse intrahepatic cells during liver injury and reconstruction. Thus, Notch signaling may serve as a potential therapeutic target for liver diseases.