P139 Articular manifestations in inflammatory bowel disease – results from Northeastern Romania

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Background: The presence of extraintestinal manifestations (EIM) in inflammatory bowel disease (IBD) is a common and well known finding. Among these, joint involvement is one of the most frequently associated.

Methods: Using the national database IBD Prospect, we conducted a prospective case-control study that included 325 patients diagnosed with Crohn's disease (CD) or ulcerative colitis (UC). Between these cases, 81 (24.92%) were classified in the group CD, 242 (74.46%) having UC and 2 cases (0.62%) were classified as having undifferentiated colitis Among them, 30 patients (9,23%) had EIM including 24 cases of articular manifestations. Regarding joint events, we found 5 cases of arthiris, 10 cases having axial manifestations like sacroiliitis or ankylosing spondylitis and 9 cases of multiple EIM including articular damage.

Results: In both study arms, articular manifestations occupy the first place into EIM (14/17 CD vs 10/13 UC, 82.35% vs 76.92%, p=0.927). Into the group of CD patients, joint manifestations first correlated with the ileo-colonic form of CD (8/14; 57,14%) followed by the colonic involvement (4/14; 28,57%). Into the UC arm, joint damage was associated with an extended colonic involvement (4/10; 40%) followed by proctitis and left side colitis. Both groups of patients with articular manifestations were associated with a moderate form of IBD activity - 10/14 CD vs 5/10 UC (71.43% vs 50%, p=0.199).

Conclusions: In Northeastern Romania predominate UC cases. Most patients included in this study and having EIM belong to CD phenotype. Articular manifestations occurred at a higher frequency in patients with CD as compared to those diagnosed with UC. The most common articular manifestation is the axial involvement, followed by peripheral arthritis.

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