Background: The diagnosis and evaluation is quite complex for inflammatory bowel disease (IBD). An ideal, noninvasive marker is quite urgent for IBD. Fecal S100A12 is a member of the S100 protein family and secreted by activated neutrophils. We aim to evaluate it as a biomarker for IBD patients in China.
Methods: Fecal S100A12 was measured in 18 Crohn's disease (CD), 21 ulcerative colitis (UC), and 17 healthy controls (HC). Diagnositic value was evaluated by receiver operating characteristic (ROC) analysis in comparison with C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). The correlation between fecal S100A12 and clinical characters were also evaluated thereby.
Results: There are significantly increase in both UC and CD when compare to HC (p<0.01, p<0.01; respectively). The fecal S100A12 is correlated with fecal occult blood (p=0.02, r=0.55) in UC. However, the fecal S100A12 is correlated with disease duration, ALB, and PLT in CD (p=0.01, r=0.53; p<0.01, r=−0.65; p=0.04, r=0.45. respectively). There are no correlation between fecal S100A12 and other clinical characters.
Conclusions: Fecal S100A12 is valuable in distinguish IBD patients with HC. However, the sensitivity and specificity is limited when compared with western countries. The correlation between S100A12 and clinical characters is limited as well. More research need to do to explore it in Chinese patients.