Abdominal vagotomy inhibits osmotically induced drinking in the rat

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Abstract

Results of a study with 35 male Sprague-Dawley rats show that after complete bilateral transection of the abdominal vagus (Vgx-C9), with the hepatic branch left intact, Ss drank later and less than normal after cellular dehydration induced by hypertonic saline. When access to water was delayed for 1 hr after cellular dehydration, Vgx-C Ss initiated drinking quickly with normal latency, but (a) a gastric water preload was a more effective stimulus for drinking suppression in Vgx-C than in normal Ss; (b) gastric emptying of a water or phenol red solution preload was more rapid in Vgx-C than in normal Ss; and (c) when gastric emptying dysfunction in Vgx-C Ss was removed by having Ss sham drink, Vgx-C and normal Ss sham drank equivalent amounts of water. Thus, disordered preabsorptive satiety caused by abnormally rapid gastric emptying of water was a factor in the decreased drinking of Vgx-C rats after cellular dehydration. Disordered satiety for ingested water could not, however, account for the abnormal latency to initiate drinking after cellular dehydration in Vgx-C rats. (29 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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