Effects of lesions of the amygdala, preoptic area, and hypothalamus on estradiol-induced activity in the female rat

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In the 1st of 2 experiments, lesions of the anterior hypothalamic nucleus and the medial preoptic area sharply attenuated enhancement of wheel running by estradiol benzoate (EB) in ovariectomized albino Holtzman rats. 71 Ss received either 3.0 μg EB or oil in daily sc injections. Lesions of the corticomedial amygdala had no effect on wheel running. The hormonal effects on activity were largely independent of any changes in body weight. Exp I indicated that the anterior hypothalamic and medial preoptic areas are critically involved in the induction of activity by estradiol. However, this experiment provided no support for suggestions that the corticomedial amygdala inhibits those structures that mediate the estrogenic induction of activity. In Exp II, food deprivation was used to stimulate activity. Results suggest that the reduction in the ability of estradiol to induce activity following anterior hypothalamic and medial preoptic lesions does not reflect a general inability to become more active. (23 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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