Acute homeostatic imbalances reinstate sensorimotor dysfunctions in rats with lateral hypothalamic lesions

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Abstract

It has previously been demonstrated that rats recovered from aphagia and adipsia after large bilateral electrolytic lesions of the lateral hypothalamic (LH) area do not show the normal feeding response to 2-deoxyglucose or drinking response to polyethylene glycol. The present work found that such homeostatic imbalances reinstate the profound sensorimotor impairments that are seen in the immediate postoperative period but abate in parallel with the gradual recovery of ingestive behaviors. Administration of alpha methyltyrosine or spiroperidol produced sensory and motor dysfunctions in male albino Sprague-Dawley rats with LH lesions that were similar to those observed after 2-deoxyglucose. Results suggest that the residual feeding and drinking deficits of Ss with LH lesions after apparent recovery of function do not reflect specific loss of putative gluco- and volume-regulatory contributions to ingestive behavior. Instead, they indicate continued impairments in nonspecific activational components of motivation that normally are mediated, in part, by central dopaminergic neurons. (29 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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