Ontogeny of cholinergic mediation of behaviors in the rat

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In 6 experiments with 159 immature Sprague-Dawley rats it was found that although scopolamine disrupted discriminative choice behavior in both 15- and 23-day-old pups, it increased latency to choice in 15-day-olds and decreased it in 23-day-olds. This disruption of discriminated choice behavior was not due to differential shock thresholds or differences in locomotor activity between drug-treated and control Ss, nor was it specific to a T-maze shock-escape discrimination task. Results suggest that central cholinergic mediation of different behaviors may mature at different rates. (26 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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