Energetics of the Na+ Pump in the Heart

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Movement of ions across the cell membrane is driven by the free energy released from ATP hydrolysis. Here we will briefly review the chemistry of Na+, K+-ATPase reaction; we will also review some recent results defining the relationship between the energetic driving force and Na+ efflux by the Na+ pump in the normal myocardium and then discuss this relationship for pathophysiologic states in the heart.

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