Computed tomography (CT) has the ability to deteet small variations in tissue density. Meglumine diatri/oate was given intravenously to four patients with clinical acute cholecystitis as part of the CT scanning procedure. The enhancement of the thick gallbladder wall. together with an enlarged gallbladder and the presence of stones, confirmed the diagnosis of acute cholecystitis. Our present experience indicates that alter contrast medium administration. CT has a distinct place in the assessment of acute inflammation of the gallbladder.