Extracapsular Extension of Prostate Cancer: Diagnostic Value of Combined Multiparametric Magnetic Resonance Imaging and Isovoxel 3-Dimensional T2-Weighted Imaging at 1.5 T

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Abstract

Objective

The objective of this study was to assess whether adding isovoxel 3-dimensional T2-weighted imaging (volume isotropic T2-weighted acquisition [VISTA]) to multiparametric magnetic resonance imaging (mp-MRI) improves the ability to diagnose the extracapsular extension (ECE) of prostate cancer.

Methods

Two radiologists independently evaluated ECE on images acquired with mp-MRI only (method A) and mp-MRI plus VISTA (method B) in 50 men who had undergone prostatectomy. We also compared the signal-to-noise ratio of the tumor on T2WI and VISTA scans.

Results

Sensitivity, specificity, and accuracy were higher with method B. For both readers, specificity, accuracy, and the area under the receiver operating characteristic curve of method B were significantly higher than those of method A (reader 1: P = 0.028, 0.025, and 0.006; reader 2: P = 0.017, 0.0071, and 0.018). The signal-to-noise ratio was significantly higher on T2-weighted imaging than VISTA images (9.21 [SD, 2.46] vs 7.30 [SD, 1.87], P < 0.01).

Conclusions

The addition of VISTA to mp-MRI improves the diagnostic value for ECE significantly.

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