[131I]Iodometomidate for Targeted Radionuclide Therapy of Advanced Adrenocortical Carcinoma

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Abstract

Context:

In advanced adrenocortical carcinoma (ACC), many patients have progressive disease despite standard treatment, indicating a need for new treatment options. We have shown high and specific retention of [123I]metomidate ([123I]IMTO) in ACC lesions, suggesting that labeling of metomidate with 131I offers targeted radionuclide therapy for advanced ACC.

Objective:

Safety and efficacy of radionuclide therapy with [131I]IMTO in advanced ACC.

Design/Setting:

This monocentric case series comprised 19 treatments in 11 patients with nonresectable ACC.

Patients and Intervention:

Between 2007 and 2010, patients with advanced ACC not amenable to radical surgery and exhibiting high uptake of [123I]IMTO in their tumor lesions were offered treatment with [131I]IMTO (1.6–20 GBq in one to three cycles of [131I]IMTO).

Main Outcome Measure:

Tumor response was assessed according to response evaluation criteria in solid tumors (RECIST version 1.1) criteria, and side effects were assessed by Common Toxicity Criteria (version 4.0).

Results:

Best response was classified as partial response in one case with a change in target lesions of −51% from baseline, as stable disease in five patients, and as progressive disease in four patients. One patient died 11 d after treatment with [131I]IMTO unrelated to radionuclide therapy. In patients responding to treatment, median progression-free survival was 14 months (range, 5–33) with ongoing disease stabilization in three patients at last follow-up. Treatment was well tolerated, but transient bone marrow depression was observed. Adrenal insufficiency developed in two patients.

Conclusions:

Radionuclide therapy with [131I]IMTO is a promising treatment option for selected patients with ACC, deserving evaluation in prospective clinical trials.

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