Biloma formation has not been reported to occur after a routine percutaneous liver biopsy. It is an uncommon yet well known complication of laparoscopic cholecystectomy. We report the development of a biloma within 1 week after a liver biopsy with a Jamshidi needle in a non-cirrhotic patient with hepatitis C. The biloma was large and caused a dramatic alteration of the hepatic contour and displaced the liver medially, resulting in gastric outlet obstruction. The biloma was treated successfully with percutaneous drainage. We believe this to be the first report of a large biloma causing gastric outlet obstruction as a complication of percutaneous liver biopsy.